Human Herpes Virus 6 (HHV-6)
Human herpesvirus 6 (HHV-6) is the common collective name for Human herpesvirus 6A (HHV-6A) and Human herpesvirus 6B (HHV-6B). These closely related viruses are two of the nine herpesviruses known to have humans as their primary host.
HHV-6A and HHV-6B are double stranded DNA viruses within the betaherpesvirinae subfamily and of the genus Roseolovirus. HHV-6A and HHV-6B infects almost all of the human populations tested. HHV-6A has been described as more neurovirulent, and as such is more frequently found in patients with neuroinflammatory diseases such as multiple sclerosis.
HHV-6B primary infection is the cause of the common childhood illness exanthem subitum (also known as roseola infantum or sixth disease). Additionally, HHV-6B reactivation is common in transplant recipients, which can cause several clinical manifestations such as encephalitis, bone marrow suppression and pneumonitis.
See D K Braun, G Dominguez, P E Pellett for a review and http://hhv-6foundation.org/ for the latest in research on HHV-6.
Subcategories
HHV-6 Open Reading Frames
An open reading frame or ORF is a portion of an organism's genome which contains a sequence of bases that could potentially encode a protein. In a gene, ORFs are located between the start-code sequence (initiation codon) and the stop-code sequence (termination codon).
HHV-6 Assays and Components
Ready to use assays as well as components for your kits. Immunofluorescence, ELISA, western, PCR and more.
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HHV-6 Antibodies
Monoclonal and polyclonal antibodies to proteins of the virus as well as non-structural regulatory and assembly proteins. All have been evaluated for IFA and western blot function.
HHV-6 Antigens
Infected cell extracts, nuclear extracts, density gradient purified virus, glycoprotein fractions and more. Many are characterized with a full SDS-PAGE and western blot profile.
